Have been taking Lisinopril 10mg for less than a year and without positive effects at all. My doctor figured it was a low dose anyway and spiked it up to 20mg and I have been so sick it makes me not want to live anymore. From unexplainable constant nausea and vomiting up to several times per day to stomach wrenching pain and electrolyte imbalance manifested in my kidneys and all the way down my legs by constant fasciculations (involuntary nerve firing, very painful indeed). Needless to say I stopped the medicine without even consulting my doctor. I have never been so sick in my life!