About a week ago I was having a severe headache that had not subsided for about two days. I knew it wasn't a migraine because I had suffered with migraines before and the pain was not at all similar. The symptoms I was having were fatigue, severe weakness, and the two day headache. The doctors then ran the usual blood tests and ruled out my adrenals for the fatigue and weakness issues. Just as a side note, I also suffer from Depression and Anxiety so keep that in mind as I continue. The doctor decided to give me Reglan with Benadryl in my IV. Bad choice! About 20 minutes later I started to feel droggy and in an altered state of mind. I felt as if my body was heavy and my sense of tough was lessoned. Then the fun part came. Without my control my left arm would shot up straight in the air as if I was a 6 year old trying to get the attention of my teacher. It was horrible because I would feel a tingling sensation right before it would occur. So I started to time the sensation and hold my arm down, however, I almost hit my mother who was beside me. So just to recap, here I am sleepy, droggy, in another state of mind, and with my hand flinging in the air. I was not a happy camper. Did I mention this all toke place at 2-3 in the morning! The doctor just told me that the reaction was an adverse reaction that some patients get. Thanks Doc ;)! The only way to offset the Reglan is by administering more Benadryl. So if you are ever found in the position where you are having an adverse reaction to Reglan try some Benadryl. The next day when the rest of my panels came back I have hypothyroidism, which means that my body does not produce enough thyroid enzymes to support my thyroid function. Hypothyroidism causes depression, weight loss or gain, fatigue, weakness, and many more symptoms. Good Luck to everyone and stay off the Reglan not a fun trip to be on.....