I've been on Doryx for a few weeks now. My mood has changed a lot. I am a creative writer and I have not written anything new since I started the medication. I am taking it for acne and it works but it is affecting me mentally. I have no desire or new ideas to write. I've even gotten bad with my spelling and I used to be an Ace at that. I may just get off of it because my writing is my livelihood (fyi, i just second guessed the spelling of livelihood as I am typing this).