I have been taking Sulfameth/Trimeth for a presumed UTI/kidney infection. I was given a 2 per day regimen for 30 days. I am almost half way through and cannot take it anymore. I have experienced nausea, hot flashes (and I am man!), sleeplessness, photosensitivity and now my whole chest cavity and stomach feel raw and inflamed. I do not the diarrhea that others complain about, but I am taking a potent probiotic. The nausea and raw stomach subside when I eat, but that only lasts for a couple of hours max.