The experience is not with me, but my daughter, who is a sufferer of PCOS and experienced acne problems She's been on Ortho Tri-Cyclen Lo since January 2007, and received positive results for acne and regulating menstrual cycle, with minimal side effects. Since being switched to generic tri-lo sprintec (July 29), she's experiencing lethargy, some headaches, moodiness, acne, and slight depression, which is very unlike her. What I recommend to everyone on this website is to submit adverse event to the pharmaceutical company, Teva. They should have a website and or a call line for presenting your concerns. I will be doing this because this drug definitely needs to be reported and possibly pulled from the market.