Within 12 hours of my first dose, I started experiencing irritability, racing of thoughts, rapid heart beat, shortness of breath, nausea, sweating, and then ultimately, a panic attack. I have history of successfully treated depression from several years ago, yet this med brought forth all those painful old feelings of angst. I am discontinuing doxy immediately. I wish that one of the warning labels on the Rx bottle read, "Do not take if there is a history of depression." It sounds like that would have save a lot of people a lot of grief. Best wishes to all for good health.