Wow, am I ever glad I found this site. I'm taking Bactrim for Pouchitis. I thought surely I was going crazy. Just a few days after starting the meds, I ended up in the emergency room because of a headache so severe and fever I thought I had meningitis....I was treated with a Zpack and sent home with a diagnosis of Sinusitis. I had even told the doctor that I just started Bactrim and she said it shouldn't cause these symptoms. Not long after the episode with headaches and fever, I began having joint aches primarily in my legs, but now it's starting up my back. I called the Dr. that prescribed it today, but plan on stopping it whether he recommends to or not. This is crazy...also noticing signs of depression and fatigue...