OMG!!!! Okay, I have had the Mirena since may 2007! Over the past two years I have been through more testing than I care to admit... Severe and constant nausea, headaches, anxiety, depression, acne, sleepless nights, joint pain, no sex drive whatsoever ( my poor poor husband), lack of energy, and just overall moody! I have asked my doctors many times if it could be the mirena causing this.... No! I have also gained about 20 lbs over the last 6 months! I am normally 106 and have never in my life been able to gain weight! This is insane!!! I am calling my doctor today to get this thing taken out of me!!!! Thank you to all the women who have posted! I just thought I was going crazy...