i am getting back on topamax for the second time....the first time i lost a tremendous amount of weight. i am on it for migraines...working my way up to 200mg from 50mg. I am experiencing that memory lapse (having something i want to say on the tip of the tongue) all soda taste flat. Nausea and menstrual cycle is changing up. Been on meds 6 days so far lost 2-3 pounds. I have seen a lot of people say they have not lost weight the second time around. Is there anyone who has? I have definitely seen a change in my appetite at week one. I had the tingling in toes and feet the first time around but nothing yet. first time around it lifted my mood and I had tons of energy. It helped with my migraines that i had everyday for a year. Lost my insurance when I lost my job so now I have been able to start up again.