I took ortho-tricycline low for 6 years with no problems whatsoever. At 18 my doctor switched me to Yasmin, by my 28th day on Yasmin I had a intense dull pain in my left hip/groin area and the of my knee and calf area. After two weeks of putting it off as a sprain, it had only gotten worse, my entire left leg was swollen to about twice the normal size and had purplish discoloration and I was could barely walk or sit. I was taken to the ER where they diagnosed me with a DVT the size of a softball in my left thigh. I spent two weeks in the hospital on narcotic painkillers and IV Coumadin before they would let me go home. I spent an additional 6 weeks at home on light duty and bed rest. I stayed on Coumadin for a year before it almost killed me as well. Today I am 23 years old and still feel the effects of the clot I had 5 years ago. My leg a calf are still swollen, though not nearly as bad and anytime I'm on my feet or have to sit in a chair all day I have to deal with moderate pain. I wasn't on Yasmin on Yasmin long enough to experience any other side effects but I would strongly advise you do your research before taking this medication.