Within 5 hours of first dose, I had "severe body aches" like those with the flu. My joints and muscles hurt so much that night that I had to call my parents to help me take care of my kids the next morning. I told the doctor who prescribed it, and he said to try to stick it out for the week...what horrible advice! Thinking it was crazy advice, I reluctantly took doses 2, 3, and 4 and experienced the joint/muscle pain each time, but I guess I just somehow tolerated it as if I had the flu. My hands became rather puffy as well. After the 5th pill, I woke up in the middle of the night with HORRIBLE joint and muscle pain, which was so awful that I could barely move; I was able to move a little bit, with extreme pain all over my body--particularly my knees, wrists/hands/thumbs, feet, and shoulders. I felt and heard unnusual snapping, cracking, and popping all over my body when I would move around at all. I stopped the med immediately, and noticed some improvement over the next several days. It has since been 9 days since the last dose, and I still have considerable pain in my knee, my thumbs/wrists, and arms. Unable to do my regular exercise, I tried gentle swimming and light water aerobics several days ago, but found even that to be too painful to do. I'm still unable to pick up my young children, drive without pain (mostly in right knee and muscles connecting to it, when pushing the brake) and am still somewhat limited in typical daily activities. Also, for the last 5 days or so, I've had a strange nodule present on a tendon in my thumb which has been hurting since taking the antibiotic. This has been a very frightening experience, to say the least.