I am on my first pack of Loestrin 24 Fe. So far I am already having mood swings, some depression, crying for no apparent reason, and spotting. No headaches so far. But I have been on other BC's before and this is not the only one with side effects. Yasmin was the first BC I was on and it did the same thing to me for the first few months. Once my body got used to it, all of my symptoms went away. I am hoping the same will happen with Loestrin. But the important thing to remember is that everyone's body is different and if the BC your on isn't working for you, then talk to your doctor about trying something else. There is no one perfect answer for everyone. I have read many of these message boards about different BC's and this one is the same as the rest. Some do well on it and some don't. Talk to your doctor.