About 2 hours after taking my 18th day of generic Wellbutrin XL 150mg. (Sun)the palms of my hands started itching like crazy! No bumps or anything, just intense itching. I immediately applied 1% Hydrocortisone cream to them and after about 10 minutes that pretty much made all the itching go away. I didn't want a replay of that, so I kept applying the HC about every 4 hours all day long, or after washing my hands. That evening everything was okay. Then the next morning, my hands started itching again...so again I applied the HC cream again, and headed off for work...they itched SO bad, and this time it took about half an hour for the HC cream to even begin to work. Then about 20 minutes into the hand itching, the soles of my feet started itching..too wierd! I was driving, so I couldn't apply it to my right foot b/c it was on the gas pedal, but I applied the HC cream to my left foot, ahhhh! Then as soon as I could, I applied it to my right foot. It took about 10 minutes, but it was soon itch free. When it came time to retake my med, I decided not to risk it. I called my prescribing doctor and she was off, and some other doc just said to take Benadryl. Duh, I was at work and #1 didn't have any and #2 it makes me so sleepy, I can't function. Then later on in the day, my wrists got welts on them, then my left elbow got a huge set of welts on it, and itched like crazy...then a few hours later, my left ankle got a huge welt on it and it looked like my ankle was swollen and both my feet and ankles had pin pricking sensations....a few hours after that, my right leg started itching behind my knee...I could feel a welt through my slacks...so again, I went into the ladies room and applied HC cream and it helped. By now I've used 1/2 the new tube of HC cream! When I finally got home, I pulled off my clothes and I had huge welts (hives) all over the back of my right leg. Plus, a big long skinny (horizontal) welt where my bra and wrapped around me. Since I was home, I could take Benadryl...so I took 4 tsp. and jumped into a warm (not hot) bath (they say to use cool water but I couldn't do it) with a cup of baking soda. Felt SOOOO good! By the time I got out they felt much better. I kept taking the Benadryl every 3-4 hours all evening but by the time I went to bed, I had welts on the back of my left leg also and on my buttocks and hips. My head kind of itched here and there in weird places, more like pin pricks but I have really thick hair, so I can't tell if I have any welts there or not. I stayed home from work today to continue on the Benadryl and making sure it doesn't get any worse. It hurts to sit here typing as my panty line is in the middle of a big 3" welt. The Wellbutrin XL seemed to be helping my depression and anger issues, but I assume the MD will put me on something else. I really liked it. It did suppress my appetite during the day but not much at night. Oh well! I'm glad I'm not the only one with these symptoms.