Been on Topamax for almost a year. My dose was 150mg once a day for alternative treatment for chronic depression. I am also on Effexor and Lamictal. The tingling in the toes has lessened but not gone away. I have severe thirst all the time. My body seems to overheat easily. I lost 20 lbs but i was doing weight watchers and had just had a baby so its hard to give all the credit to Topamax. I definitely feel dumb. Words come and simply float away out of sight. My memory is extremely affected. I can fight with my husband and by the end have no idea what I had just said. Feel quite foolish. I am now titrating down and off by 50mg every 4 days. I am down to 50mg and have not had a good night's sleep since reducing my doses. My brain just turns on in the middle of the night. I am also pretty nauseated at this lowest titration. I just gained back 6 lbs but eating chocolate doesn't help either. I seemed to be able to keep my weight at 140 lbs no matter what i would eat. Not so anymore. Always trying to find the faster, easier way toward staying thin but it always comes back to that same bottom line. I have to discipline myself boooo.