When I took SMZ-TMP DS; The day after i could not move my legs without being in agony pain. I didn't think anything about it. The next day i had painful, red knots on my ankles and as the day went on they started to grow in size and more started to appear. I immediately stopped taking the drug and called my doctor. I could not sleep cause I was in so much pain. I would lay still on my back but when it was time to get up in the morning i had to literally lift my legs with my hands and get someone to carry me to the doctors office. He said that I had a very interesting case and that to never take this medication again. Right now I am still in a lot of pain and taking anit inflammatory medication to help with the knots and pain. I am still in bed not getting up and now I have 40 knots on my legs. He called the knots Erythema Nodosum. My tissue got infected with this medication.