I have been on Methotrexate for about 1 year to treat RA. It has worked great for pain BUT I have noticed a lot of things going on that I've simply contributed to life. I have severe headaches, dizziness, extreme fatigue and major mood swings (depression and anxiety). I've seen some things posted on the internet about these being side effects. I am going to talk to my RA doctor and see if there is something we can do. I have been so bothered by these symptoms that I would just about prefer the pain to the constant feelings of irritability and depression. What are some other medications people are finding useful of RA with out the side effects????