I have been on Tri-Sprintec for over a year now. At first, i felt pretty emotionally unbalanced, so much so that I got an IUD and planned to stop. The IUD was uncomfortable and I kept bleeding. I finished the month's supply of Tri-Sprintec and had the IUD removed. After being on Tri-Sprintec for about 4 months, I felt completely normal and have no side effects. It actually made me LOSE weight and I have perfectly predictable periods. I love it.