I had been on Aciphex for about 4 years because Nexium, Prilosec, and all the other meds did not help my heartburn. I started having problems wtth my bowels, I thought I had IBS but with the diarrhea effects. It was so bad some days that I could not drive to work. I would have strong urges to go to the bathroom which literally gave me less than a minute to find a toilet. I never thought it would be the Aciphex. I recently switched to Zegerid and have not experienced quite the problems I had in the past. Last night I took my 1 remaining Aciphex and this morning the problems returned. I am sure now that the Aciphex has something to do with it. I am wondering if there is any long term damage/effects from it.