I am amazed to see so many woman going through the same things I am. I really do feel like I have been going crazy with my doctors. Since I have been on the Mirena I have experienced, weight gain, depression, nausea, excessive tiredness, cramps in my uterus and breast tenderness. I also have a hard time sexually. I cant seem to get wet either. Although my sex drive is there I still can get wet. I also have lost hair on my head and have started getting hair on my face. YUK!!!!!!Since I have been on thr Mirena for the past 2 years I have maintained my weight but have lost nothing. I am going to get it taken out really soon, since my husband was nice enough to get a vasectomy. Hopefully these mood swings and tiredness will go away.