I have had Mirena since November 2006.(3 years) It was SOOO painful to have it put in, but I know it has to do a bit with the fact that I've never had a kid. I immediately had HORRIBLE cramps for hours and bled for about 4 weeks. Since then I have not had a period at all :) Now, I am 27 yrs old and have NO sex drive, ZERO! I hope that it is because of the Mirena, lol. I don't take any other meds at all. In 3 years I've probably packed on 15 pounds, but I can't say its because of Mirena. Me and my husband are ready for kids, so I'm gonna have it taken out in January. We'll see if it helps with the sex drive :) I haven't had any other side effects really.. overall, I would use it again, just be sure to take some pain meds before you have it put in, cuz that pain is like child birth said my OBGYN.