I work for an OBGYN and I was getting samples of Ortho Tri Cyclene Lo, and had been on it for 2 years due to my cysts rupturing. Well Ortho went generic and we no longer carried it in the office and i was recommended to just try Loestrin before going to pay for an RX of my ortho. Well im in my 2nd week, and grant it i KNOW they say wait 3 months before you decide to switch but i CAN NOT take this any longer. Ortho gave me no problems, maybe cramps a few times out of the year, and with those, some heavy periods, which is normal for any pre-menopausal woman. Other than that it was great! No loestrin is almost giving me the same problems as Yaz did... yet Yaz was far worst, i am now experiencing moodiness, manic and depressive mood swings, uneasiness, nervousness, constipation, tiredness, and it really does not help that i am also in full time college while experiencing all of these side effects. I think the 35 dollars a month for ortho may just be well worth the price.