I've been on Effexor XR for a few weeks now for GAD and depression after being on Prozac for two years on and off. I dont know if its helping me or making me worse, its reduced my anxiety quite a bit, but I think its making my depression worse. I dont really know what it is, but a week after i started taking it I've started crying quite a bit. Previously I rarely cried because i felt so distant from my emotions, but now I seem to be feeling worse. The thing is I dont know if this is an improvement because I can actually feel something or if its worse because all i seem to be feeling is miserable. I cant seem to enjoy anything at all and I've lost most of my motivation since i started Effexor. I've noticed that I've become rather snappy and rude to people - this is not like me at all. I've lost all my enthusiasm for life (not that there was much to begin with) and it seems like theres nothing to look forward to. I seem to be thinking about suicide more than when i wasnt on it. I've never slept properly but now I keep on semi waking up during the night all the time. I know that its possible that my depression may have been getting worse regardless of the Effexor but i seriously think the two are related. But what worries me the most and is making me feel terrible is that Ive seen effexor advertised as an antidepressant 'for treatment resistant depression' - kinda makes me wonder that if its doing nothing good to me then what hope do i have? no wonder people are killing themselves on antidepressants - theyre advertised as some miracle cure and when they dont work then what are people supposed to do? im beginning to think more and more that im not depressed but i just have a pathetic personality that makes me sluggish and bored. feels like Effexor not working seems to confirm that.