After 3 weeks on Wellbutrin, I've experienced hives with swelling and joint pain. It took a while to actually start working. Prior to starting Wellbutrin I was on zoloft(50mgs) for a year. I experienced many side effects in the beginning with zoloft but most weared off. The most troublesome effect I got from zoloft was the sexual side effects. This is why I chose Wellbutrin. Can't really say that's it's made a difference as far as that effect is concerned. However I can say that I do feel that it's maintaining my depression from flaring up.