I've been on and off Prednisone for 11 years now. Highest dosage was 100mg, but I rarely need to get that high anymore. Although this is a particularly bad flare (Lupus) and I'm taking 80mg now. They say it's the miracle drug that kills. It saves my life now, but will destroy my body over the long run. I'm hoping someone comes up with an alternate solution. My side effects are: weight gain (but with lots of exercise and paying attention to what I'm eating, I can maintain), puffy face, for the first few days - very hyper (MUST CLEAN - strange), then low lows. Also, very important side effect to know about: mistaken feelings of being mistreated (my poor boyfriend had to get an "explain your behavior" lecture when he hadn't done anything wrong). One of the worst and most dreaded side effects is night terrors/hallucinations. I will have an AWFUL nightmare and wake up and I'm still seeing it (i.e. 4 ft spider dangling above my head).. takes 5 minutes awake for me to talk myself into realizing it's not real. I have also lost control of my bladder in the middle of the night before. These only happen on high doses (>40mg). I also get flushed and hot when the med is wearing off and I know I need to take another dose. If I'm taking >40mg/day I will space it out every couple of hours. Every body is different. I don't have the acne... but there's always time! lol... Good luck, everyone... Know your body...