I started Advair over a year ago, first 500/50 then decreased to 250/50. During the past year I have steadily gain 50 lbs, severe muscle and joint aches, as well as depression, forgetfullnes, and confusion. There were also a few periods where I had brief blackouts. In April of this year, I bought a treadmill. I was not able to walk over 2.0 mph or for longer than 1/4 mile. I started having chest pains. I went to the doctor and they admitted me to the hospital for heart tests. The tests came back negative, but they found that I had extremely high thyroid levels. My TSH level was 80.76 (normal is 3-5) and I was diagnosed with hypothyroidism. All of the above symptoms are also symptoms of hypothyroidism. My symptoms started to improve after taking the thyroid medication. However, at the same time my asthma improved and I stopped taking Advair. Three weeks ago I had to begin the Advair again and now I am starting to gain weight with muscle tightening and weakness. After reading this site, I now believe my symptoms were more from the Advair than the hypothyroidism. I will no longer use Advair. I would rather be on prednisone than have to experience these side effects.