I have been on many different birth control pills for the past four years. My first was Orth tricyclin, that made me very tired, withdrawn and irritable. I was switched to Desogen one year ago and have had MANY problems. I have been very irritable, very low sex drive, and short tempered. I will be looking for a new birth control ASAP now that I know that these side effects aren't chalked up to just stress. Thanks for all of the others who have added their 2 cents to help me make my decision.