I got a bad case of poison ivy & was put on prednisone--50 mg for 2 days, 40 mg. for 2 days (no improvement) so went back to the doctor and he put me on 80 mg for a day then 50 mg for 3 days then 40 mg., and I was so crazy I went to 20 mg then quit it altogether. The poison ivy never went away. I was very depressed, no energy, bloated, hungy, lethargic (which no one seems to have mentioned), no initiative, and everything I do is a total effort on my part. I could just sit and stare at nothing, and this is NOT me! I have severe itching, burning, bruises, weight gain, and I just don't feel like myself at all. I was never so glad to get off any drug in my life, and I hope I don't ever have to take it again as I did not sleep, felt "out of it", couldn't think straight, and felt so discouraged and helpless--the helpless is gone after I'm off, but I just don't have any energy and am so mad about that and the weight gain! I could eat everything that is not tied down. Also, night sweats terribly and lots of hot flashes where I break out in sweat and am about to ruin my clothing. Having to do laundry constantly of sheets, clothing, towels, etc. I would recommend no one take this drug unless it is a last resort.