I have been on 250/.50 for three yrs.now. I have the severe muscle cramps and arthritis in both wrist and an all over aching! I HAVE DEVELOPED CHEST PAINS ALMOST DAILY. I tried to go off the advair on my own, what a big mistake!! I had muscle cramps in both legs , tummy, and arms so severely I ended up in th ER. JUST THIS YEAR; My gallbllader ruptured and had to be removed and a week long stay in the hospital. I honestly believe Advair has caused all my medical problems. I am not sure what to do or take in place of advair. my asthma is under control, but;I am still on advair. I want to goff it again, but;my doctor says absolutely not.. I hate the stuff!!