I just started Depakote about a month ago. I'm just now getting what I believe to be "side effects" or they could be from a mixture of meds that I take (Zoloft and wellbutrin in the morning, and Depakote Temazapam and amblify at night). I am haveing hair loss...which is fine with me cuz my hair is so thick anyways. I'm starting to lose weight, and lately my legs have been hurting. As of the last week or so I've become a total bitch. I am irritated all the time and wish people around me would just leave me alone. There is a good chance that I may even end my relationship....just on a count of my moods and bitchiness. I see the Dr on the 2nd so hopefully there is a happy median somewhere