Worked up to 50 mg. for depression/anxiety with a noticeable improvement in my mood and only a few minor side effects the first week including intestinal irritation. Then after 5 months it seemed to make me tired/apathetic all the time. I weaned myself off but couldn't handle the fogginess during this time. Went back on just 25 mg. but again after about 5 months I felt lazy all the time and again am now weaning myself off. It has been a week and I am trying to make it through the spaced-out feeling and dizziness. I'm researching St. John's wort now and may give it a try.