well ive been on effexor for about 2 years and im recently on 150 mg and yes it can make u feel very sick and strange b/c i had panic attacks all the time for the first two weeks. then my body got use to it,and there are days when i feel lifeless b/c i dont really cry anymore b/c my doseage is so high and its under control but im only 17 so my mom and doc control all my meds..but youll get use to the effexor..