I was prescribed Guaifen PSE ER Tabs for my ears and also an antibiotic for my sore throat. I have noticed a mild loss of appetite. I also flew to Montana for a wedding and my ears wouldnt unpop after we landed, they are still acting a little funny after 4 days. I was instructed NOT to take before bed, but twice daily earlier in the day because if does cause problems when trying to fall asleep.