hi Janeanne, I have taken Wellbutrin for several yrs and seems the best AD for me. I did not notice memory loss, now I have, but is from the Lamictal and Neurontin. Am hoping to get rid of one of them. What you might be interested in is that I began taking the time release300 in AM and felt in a fog-like disconnected for a few hrs in the AM. Went back to the 150 3X a day and went away. Began taking 2 150 in the AM (pdoc thinks the later dose may be adding to not getting to sleep) and 150 later in afternoon and noticed in AM feeling the same way. Had to stop doing it 2 weeks when had to learn some new programs at work and needed to be sharp in AM. Lindagail