I HAVE BEEN ON SEROQUEL FOR SEVERAL MONTHS. iT IS THE ONLY MEDICATION THAT GIVES ME A FULL NIGHTS REST. I don't want to give it up but the fact is I am always tired in the mornings. I can't think as sharply. It doesn't wear off until mid afternoon. I only take 1/4 of a 25 mg. tablet nightly. I don't have schizophrenia. I have bipolar disorder.