I have had it prescribed for acne. So far so good. I do feel the disconnected feeling, and get hot flashes here and there, even though I'm only 27. I feel very lethargic and lose focus. I feel some what uncomfortable in my own skin... that something is not right with my body. I haven't taken it for long to see the improvements. I'm not getting nausea, which is a good thing, I definitely make sure to take it with food. I tried Amoxycycline, and that made me feel awful..I was green with nausea, so this stuff isn't half has bad, just don't like the medicine head feeling.