Switched from Zestril to Lisinopril in Jan 2004 - Starting in February have had incredibly severe leg crams eleven times; numbness and tingling in arms a couple of times; extreme fatigue; dizziness and light headedness, large weight gain. Numerous medical tests have not revealed cause. Visited a dietician today to discuss weight gain, and she immediately connected my syptoms as a possible side effect to Lisinopril, and suggested I discuss the possibility with my doctor. Internet research indicates many others have similar symptoms from Lisinopril.