Amazing stuff at this site. I have rheumatoid arthritis and am taking Pred, which acted like a miracle, stopping my excruciating joint pains and enormous fatigue. But even at the low dose of 5mg, I had frightening mood changes, irritibility, suicidal thoughts, reclusiveness, wanting to hide, and difficulty with abstract thinking. I reduced to 4mg, then to 3mg and suddenly I have returned to normal. I have much more energy, and the mental/emotional symptoms have gone. Prednisone is very powerful drug, but one that should be used with extreme care. My MD did try to bring down the dose as much as possible. My impression is that many MDs are prescribing much too much.