I have had asthma for over 20 years. I am now 25 and have been on Advair for over 2and 1/2 yrs. Advair definitely has helped, I can breath enough to run again, no wheezing or struggling for breath no hospital visits since I started the med....BUT I have also gained over 40 pounds (and still gaining), get chronic migraines, and have definite Cushing's like symptoms. Plus I get thrush in my mouth every couple of months. And don't forget the insomnia, jittery feelings, tremor and rapid heartbeat. All of these symptoms started since I began taking Advair and continue to worsen. And to top it off, my Pulomonlogist insists the Advair cannot be causing all of these problems. I thought I was losing my mind until I found this forum. Advair is no miracle drug and should be taken with extreme caution.