I have been taking Prilosec and Omeprazole for more than 5 years. I have had trouble with itching, dizziness, and now, tinnitus. The itching which was intense on my calves was solved by washing with a wash cloth and not taking a shower or bath, as my doctor recommended.
The dizziness comes and goes. The tinnitus is new. My pharmacist said that tinnitus usually starts immediately upon introduction of the drug, but it is possible for it to occur at any time. Over the years I have identified the foods which cause distress (most food), and I am extremely careful. One bite of, let's say, pizza, will cause a great deal of gastro distress for days.
I also feel like I am completely dependent on the Omeprozole, because I get ill within 1 to 2 days if I do not take it every day.