Having my first flare-up in nine years of ulcerative colitis. Other meds aren't working and just started today with 40mg prednisone. I am also suffering from anxiety and depression. Very afraid of how this drup is going to make me feel. Even though I was on it before and had bearable side effects such as not sleeping, energized, and weight gain - I am now 11 years older and afraid of how I will react. I must say that because of this drug - I did not have to have surgery and still have my colon. Hope it works just as good this time.