I've been on Zoloft for 2 years, and I'm at 100 mg right now, mainly for anxiety and deppression. I can honestly say Zoloft has done alot more good then harm to me. I'm actually stable and have been for awhile. Though I'm not as deppressed as I used to be, and I've had no panic attacks since it kicked in, I feel kind of an overall very mild deppression, like a fog. Also if I forget to take it for a few days I get "shocks". I've found also its not a good idea to take it at night, because recently I've been remembering vivid dreams alot more, and a few times needed a reality check. Its good that I don't cry constantly I like I used too, but now it takes ALOT for me even to shed a tear.