I have been on Advair 100/50 for over 2-1/2 years and it's the best thing I've ever taken. It increased my lung capacity 33.5% and I do not wake up at night with asthma attacks. I don't have to depend on my Albuterol for rescue all the time either. I took Azmacourt 4 times a day prior and constantly had shortness of breath and asthma issues. I've been very fortunate on Advair! I have not had insomnia, difficulty sleeping, no musle weakness, no heartburn, and no rashes. I have had slight weight gain, and managed to get it off. I have constant allergies and allergic rhinitis so I do get occasional headaches. I can actually take a deep breath and not cough my head off. I can actually run and workout now! I do get dry mouth but that's easy enough to deal overcome. I may be an exception but it's a blessing for me! I take Allegra too and it is the best thing I've taken too. Seldane is better but they took it off the market. So I guess it works for some! Thanks.