I had two shots of lupron for uterine fiboids and the side effects are terrible. I had a migraine today and was unable to work. I went to the doctor and he said headaches were not a know side effect. Other effects I have experienced include: memory problems, sweating, no sex drive, hot flashes, insomnia, headaches. I haven't read that lupron can cause blood clotting but I am sure anything is possible with thisdrug. Anyone know how the side effects last after stopping drug??