I have been on zoloft 50mg per day for about 1 1/2 months for depression. I have experienced weight loss/decreased appetite and vivid dreams. Luckly, I haven't had any negative side effects. The weight loss is fine for me and the vivid dreams aren't bad. My depression is totally gone and I feel great. I also noticed I am much more outgoing, making new friends, and trying things I never would have. I then realized that I had been suffering from social anxiety disorder and since being on zoloft it is almost completely gone. I feel amazing and am so happy. For those of you that find that you are experiencing negative side effects it may just not be the drug for you. For some people, like me, it can do wonders.