I have been on Synthroid for 2 years now. I started out taking .25 and went all the way up to .75. I have since switched doctors and after he reviewed my records he feels I never had a thyroid problem. He has me going off of it slowly and I'm already feeling better. While on the medication I had major hair loss, gained 20 pounds, tired all the time, bloating, constipation and just felt bad. I'm hoping all of the side effects stop. I hate feeling so fat!! If any one else has gone off of Synthroid please let me know. Thanks!