Took Wellbutrin 2 years ago to stop smoking, 2 weeks and 3 days after taking I woke up with flu like symptoms so I took some Ibuprofen. I broke out into big wheals and hives all over body. Not sure what caused reaction Wellbutrin or Ibuprofen, but I never got the flu. After reading posts it seems quite common for this to happen on Wellbutrin. However, if you were to ask dr.'s,pharmacists or allergists they say it is more likely ibuprofen. It seems after reading here that they are not very well educated re: side effects. Also have joint pain and swelling that I still have to this day. Good news, I did quit smoking, never want to go through that again. Hives lasted for a month.