weight gain, hair loss, I feel tired all the time. I have lost interest in doing anything. Nothing excites me any longer. It is like I have lost my passion for life. When I first got on methadone it gave me energy and wieght loss but now it is the complete opposite. I want off this drug and was having the Doctor bring me down 5 mil a week and when I hit 20 mil, I got very sick and they had to raise me up to 40. They said going down 5 a week was way too fast. I don't know what is right. But since this drug no longer works for me, I can't see any reason to be on it. It is a waste of my money.