I have been taking Lipitor 20mg for six years and Lipitor 40mg for the past year. Within the past eight months I've had problems with leg pains and twitching. For the past four month I've also experienced promlems with my hand and arms. I feel tired and run down all the time. I'm now at the point where I can hardly walk as my knees feel like they will buckle at any time. I've had a number of test that for MS, ALS, HIV, lime, stress you name it and all have shown there was not a problem. "All" six of the doctors who treated me state that Lipitor would not cause this problem. Every time I try going off the Lipitor my cholesterol shoots up over 350. Does anyone have any recommendations? I'll soon be getting a wheelchair.