I have tried five different birth control pills including Desogen, Ortho tri-cyclen, Mircette, Alesse, and Yasmin. Desogen was by far the absolute scariest. After being on Desogen for just a week I found myself severly depressed and even contemplated suicide, which I had NEVER in my entire life even though about. I had horrible mood swings and a feeling of impending doom for no reason at all. As for the other pills, Ortho tri-cyclen and Yasmin has similar side effects like moodiness, weight-gain, breast tenderness, breakthrough bleeding, and fatigue. Alesse and Mircette had less of the mood side effects for me but they did both cause breakthrough bleeding and vaginal dryness. I had breakthrough bleeding on Alesse for the entire year and a half I was taking it. That will make you not want to have sex.