I have been taking Prilosec for several years without any side effects..My husband picked up script for me at pharmacy. They were out of Prilosec and filled script with Omerprazole. I have been taking this med for about a month now. Recently I have noticed muscle spasms, heart palpitations, headaches, night sweats. I asked the pharmacist yesterday if this could be related to this medication. She stated that yes this could be related. I will be switching back to Prilosec ASAP.